CAS104987-12-4
11011-38-4
EINECS600-627-5化學(xué)式C43 H69 N O12
分子量792.01InChIInChI=1/C43H67NO12/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)44-16-12-11-13-31(44)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)52-7/h18,20,25,27-32,35-39,45,51H,10-17,19,21-23H2,1-9H3/b24-18-,26-20+/t25-,27-,28-,29+,30-,31+,32-,35-,36+,37+,38-,39-,43-/m1/s1InChIKeyZDXYNMSA-N密度1.19±0.1 g/cm3(Predicted)熔點(diǎn)153-157°C沸點(diǎn)868℃閃點(diǎn)>110°(230°F)水溶性Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; withwarming. Very poorly soluble in water溶解度可溶于甲醇、乙醇、DMSO等有機(jī)溶劑折射率1.543酸度系數(shù)9.97±0.70(Predicted)存儲(chǔ)條件Inert atmosphere,Store in freezer, under -20°C外觀粉末物化性質(zhì)儲(chǔ)存條件:?20℃
WGK Germany:3
RTECS:KD4185000體外研究Ascomycin,從鏈霉菌中分離,抑制小鼠混合淋巴細(xì)胞的體外免疫應(yīng)答,IC50 為0.55 nM。Ascomycin通過FKBP12-FK520鈣調(diào)磷酸酶三元復(fù)合物的形成抑制鈣調(diào)磷酸酶,IC50為49nM。FK520也會(huì)加速神經(jīng)修復(fù)率,也會(huì)促進(jìn)神經(jīng)突增生。Ascomycin通過抑制兩種不同功能蛋白的分子伴侶活性表現(xiàn)出抗瘧作用。