CAS2390-54-7
EINECS219-228-9化學(xué)式C17H19ClN2S
分子量318.86InChIInChI=1/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1密度1.301g/cm3 at 20℃熔點(diǎn)211-212 °C (decomp)蒸汽壓0Pa at 25℃溶解度甲醇: 可溶物1mg/mL存儲(chǔ)條件Store below +30°C.外觀粉末顏色Yellow to ochre-yellowBRN3922452MDL號(hào)MFCD00011944體外研究Thioflavin T (ThT) is a benzothiazole dye that exhibits enhancedfluorescence upon binding to amyloid fibrils and is commonly usedto diagnose amyloid fibrils, both ex vivo and in vitro. In a, Thioflavin T is found to exist as micelles atconcentrations commonly used to monitor fibrils by fluorescenceassay (~10-20 μM). Specific conductivity changes are measured atvarying concentration of Thioflavin T and the critical micellarconcentration is calculated to be 4.0±0.5 μM. Changes in thefluorescence excitation and emission of Thioflavin T are alsodependent on the micelle formation. The Thioflavin T micelles of 3nm diameter are directly visualized using atomic force microscopy,and bound Thioflavin T micelles are observed along the fibrillength for representative fibrils. Increasing concentration ofThioflavin T above the critical micellar concentration showsincreased numbers of micelles bound along the length of the amyloidfibrils. Thioflavin T micelles are disrupted at low pH as observedby atomic force microscopy and fluorescence enhancement uponbinding of Thioflavin T to amyloid fibrils also reduced byseveral-fold upon decreasing the pH to below 3.The micelles ofThioflavin T bind amyloid fibrils leading to enhancement offluorescence emission.安全術(shù)語(yǔ)24/25 - 避免與皮膚和眼睛接觸。
危險(xiǎn)品運(yùn)輸編號(hào)2811WGK Germany3TSCAYes海關(guān)編號(hào)32041300Hazard Class6.1(b)Packing GroupIII上游原料2-(4-氨基)-6-甲基苯并噻唑參考資料 

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1. 王瑞 朱文清 鄭潔 等. 原兒茶酸對(duì)人血清白蛋白淀粉樣纖維化的抑制作用[J]. 分析科學(xué)學(xué)報(bào) 2020v.36(02):14-18.2. 郝徐藝, 羅思, 程淑意,等.當(dāng)歸芍藥散對(duì)AD細(xì)胞模型銅離子介導(dǎo)的Aβ聚集的影響[J...硫黃素T - 簡(jiǎn)介

硫黃素T，也被稱為硫胺素T或維生素B1，是一種重要的維生素。
性質(zhì)：
硫黃素T是一種水溶性白色結(jié)晶性粉末，具有微弱的味。它是穩(wěn)定的，在光線、熱和酸性條件下相對(duì)穩(wěn)定。它在堿性環(huán)境下會(huì)迅速降解。
用途：
硫黃素T是一種必需的維生素，對(duì)維持人體正常的代謝功能至關(guān)重要。硫黃素T還被用于防治硫黃素T缺乏癥，該病在飲食中缺乏硫胺素T時(shí)會(huì)引發(fā)。
制法：
硫黃素T可以通過(guò)化學(xué)合成的方法制備。Zui常用的方法是以1-甘醇-3-酮為起始原料，經(jīng)過(guò)多步反應(yīng)制得硫黃素T。硫黃素T也可以通過(guò)天然來(lái)源，如酵母和谷類中提取得到。
安全信息：通常情況下，正常劑量的硫黃素T不會(huì)產(chǎn)生明顯的副作用。過(guò)量攝入硫黃素T可能導(dǎo)致胃腸道不適或過(guò)敏反應(yīng)。對(duì)于孕婦和有慢性疾病的人群，應(yīng)在醫(yī)師的指導(dǎo)下使用。