leukemia inhibitory factor (lif) is a pleiotropic lymphoid factor belonging to the interleukin-6 family of cytokines. it was initially described as a factor inhibiting the proliferation of myeloid leukemia cells and inducing their differentiation into macrophages. other activities of lif include inhibition of adipogenesis and roles in cholinergic neuron differentiation, hematopoeisis, inflammation and bone metabolism. lif inhibits the differentiation of embryonic stem cells, it is therefore important in es cell culture. human and mouse lif share 78% amino acid homology, the human version is equally active on human and mouse cells but murine lif is not active on human cells.

 

lot number    01-1-88-7124

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