中文名N-[(4-羥基-1-甲基-7-苯氧基-3-異喹啉基)羰基]甘氨酸
英文名FG-4592
別名羅沙司他
洛度司他
羅沙司他光降解雜質(zhì)
HIF脯氨酰羥化酶抑制劑(FG-4592)
N-[(4-羥基-1-甲基-7-苯氧基-3-異喹啉)羰基]甘氨酸
N-[(4-羥基-1-甲基-7-苯氧基-3-異喹啉基)羰基]甘氨酸
甘氨酸, N-[(4-羥基-1-甲基-7-苯氧基-3-異喹啉基)羰基]-
FG4592 N-[(4-羥基-1-甲基-7-苯氧基-3-異喹啉)羰基]甘氨酸
英文別名FG-4592
FG-4592(ASP1517)
N-[(4-Hydroxy-1-Methyl-7-phenoxy-3-iso)carbonyl]glycine
N-[(4-Hydroxy-1-methyl-7-phenoxy-3-iso)carbonyl]glycine
Glycine,N-[(4-hydroxy-1-Methyl-7-phenoxy-3-iso)carbonyl]-
Glycine,N-[(4-hydroxy-1-methyl-7-phenoxy-3-iso)carbonyl]-
2-(4-hydroxy-1-Methyl-7-phenoxyisoxaMido)aceticacid
2-(4-HYDROXY-1-METHYL-7-PHENOXYISOXAMIDO)ACETICACID
[[(4-Hydroxy-1-Methyl-7-phenoxyiso)carbonyl]aMino]aceticAcid
[[(4-Hydroxy-1-methyl-7-phenoxyiso)carbonyl]amino]aceticacid
CAS808118-40-3
EINECS813-400-2化學式C19H16N2O5
分子量352.34InChIInChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)密度1.389熔點199-215°C沸點684.3±55.0 °C(Predicted)溶解度Soluble in DMSO (up to at least 25 mg/ml).酸度系數(shù)2.46±0.10(Predicted)存儲條件-20°C穩(wěn)定性Stable for 1 year from date of purchase as supplied. Solutions inDMSO may be stored at -20°C for up to 2 months.外觀solid顏色Off-white or white體外研究FG-4592是一種口服缺氧誘導因子（HIF）脯氨酰羥化酶抑制劑,在臨床上用于治療貧血。FG-4592穩(wěn)定HIF的活動，HIF是細胞內(nèi)轉(zhuǎn)錄因子，導致與紅細胞相關基因，包括EPO，和參與鐵代謝相關酶的激活。