中文名孟魯司特鈉
英文名MontelukastSodium
別名孟魯斯特納
孟魯司特納
孟鹵司特鈉
孟魯司特鈉
孟魯斯特鈉
孟魯司特鈉鹽
馬尼地平鹽酸鹽
孟魯司特鈉.孟鈉
孟魯司特鈉水合物
孟魯斯特-D6鈉
英文別名mk-476
singulair
MONTELUKASTNA
MK-476,Singulair
Montelukastsodium
MONTELUKASTSODIUM
MontelukastSodium
Montelukast,Sodium Salt
sodium(R,E)-2-(1-(1-(3-(-(7-chloro)-3-(2-(2hydroxypropan-2-yl)phenyl)propylthio)cyclopropyl)acetate
1-[1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic
sodium(1-{[(1-{3-[(E)-2-(7-chloro)ethenyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl)sulfanyl]methyl}cyclopropyl)acetate
2-[1-[[1-[3-[2-[(7-chloro-2-)]vinyl]phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)phenyl]-propyl]sulfanylmethyl]cyclopropyl]aceticacid sodium salt
sodium{1-[({(1R)-1-{3-[(E)-2-(7-chloro)ethenyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetate
Methyl-[E]-(+)-1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-)-ethenyl]phenyl]-3-[2-(1-hydroxyl-1-methylethyl)phenyl]propyl]mercapto]methyl]cyclopropaneacetic acid sodium
CAS151767-02-1
EINECS604-813-7化學(xué)式C35H35ClNNaO3S
分子量608.17InChIInChI=1/C35H36ClNO3S.Na/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29;/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39);/q;+1/p-1/b15-10+InChIKeyLBFBRXGCXUHRJY-HKHDRNBDSA-M熔點(diǎn)115 °C(dec.)沸點(diǎn)750.5°C at 760mmHg比旋光度[α]/D +90 to +106° in methanol (c=1)溶解度DMSO: ≥8mg/mL at 60°C存儲(chǔ)條件2-8°C穩(wěn)定性Stable for 1 year from date of purchase as supplied. Solutions inDMSO, distilled water, or ethanol may be stored at -20°C for up to1 month.外觀powder顏色white to tanMerck14,6258MDL號(hào)MFCD00931431體外研究Montelukast是一種白三烯受體拮抗劑（LTRA），用于哮喘的持續(xù)治療以及緩解季節(jié)性過敏癥狀。Montelukast通過與肺部和支氣管中半胱氨酰白三烯受體CysLT1結(jié)合而阻斷白三烯D4的作用，防止氣道水腫，平滑肌收縮，以及分泌液粘稠。這減少了由白三烯引起的支氣管收縮，并且使炎癥較少發(fā)生。體內(nèi)研究Montelukast (6 mg/kg,每天一次，服用20天)顯著抑制OVA激發(fā)的小鼠體內(nèi)BAL液和肺組織中增多的嗜酸細(xì)胞，并且增加BAL液中IL-5水平。OVA激發(fā)會(huì)增加CysLT1S受體但會(huì)減少CysLT2受體的mRNA表達(dá)。OVA激發(fā)后，Montelukast抑制增加的CysLT1但不降低CysLT2表達(dá)。
