中文名布帕伐醌
英文名uone
別名布帕伐琨
布帕伐醌
單晶冰糖
UONE 布帕伐醌
2-[(4-叔丁基環(huán)己基)甲基]-3-羥基-1,4-萘二酮
2-((4-(叔丁基)環(huán)己基)甲基)-3-羥基萘-1,4-二酮
英文別名BW-720C
CS-1178
butalex
uone
uone-d4
2-((4-tert-butylcyclohexyl)methyl)-3-hydroxy-1,uinone
2-((4-tert-butylcyclohexyl)Methyl)-3-hydroxynaphthalene-1,4-dione
2-[(4-tert-butylcyclohexyl)methyl]-3-hydroxynaphthalene-1,4-dione
3-[(4-tert-butylcyclohexyl)methyl]-4-hydroxynaphthalene-1,2-dione
2-((4-(1,1-dimethylethyl)cyclohexyl)methyl)-3-hydroxy-4-naphthalenedione
2-[[4-(1,1-dimethylethyl)cyclohexyl]methyl]-3-hydroxy-1,4-naphthalenedione
CAS88426-33-9
EINECS618-162-1化學式C21H26O3
分子量326.43InChIInChI=1/C21H26O3/c1-21(2,3)14-10-8-13(9-11-14)12-17-18(22)15-6-4-5-7-16(15)19(23)20(17)24/h4-7,13-14,24H,8-12H2,1-3H3密度1.158±0.06 g/cm3(Predicted)熔點178-184°C沸點460.7±45.0 °C(Predicted)閃點246.536°C蒸汽壓0mmHg at 25°C溶解度DMSO: soluble折射率1.574酸度系數(shù)5.04±0.10(Predicted)存儲條件Sealed in dry,2-8°C外觀powder顏色Yellow體外研究In 4-day proliferation assays,uone efficiently inhibitsN.?caninum tachyzoite replication(IC 50 =4.9?nM; IC 100 =100?nM).uone is significantly selective against L. (L.) infantumchagasi intracellular amastigotes, with an IC 50 value of 1.5 μM.Other cutaneous species are also susceptible touone, withIC 50 values in the range 1-4 μM.體內(nèi)研究uone具有較長的血漿半衰期（至少7天）和低毒性作用（在大鼠中口服LD50大于8000 mg/kg）。