中文名牛甲狀旁腺激活素-(1-34)
英文名PARATHYROID HORMONE (1-34), BOVINE
別名特立帕肽-多肽原料委托生產(chǎn)
特立帕肽-多肽制劑一致性評價
牛甲狀旁腺激素-(1-34)
牛甲狀旁腺激活素-(1-34)
PHT激活劑(TERIPARATIDE)
受體激動劑多肽PARATHYROID HORMONE(1-34) BOVINE
英文別名BPTH1-34
TERIPARATIDE
PTH (1-34)(BOVINE)
PARATHYROID HORMONE (1-34), BOVINE
AVSEIWLRKKLQDVHNF
ALA-VAL-SER-GLU-ILE-GLN-PHE-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE
H-ALA-VAL-SER-GLU-ILE-GLN-PHE-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE-OH
ALA-VAL-SER-GLU-ILE-GLN-PHE-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHEBOVINE
CAS12583-68-5
化學式C183H288N54O50S2
分子量4108.71存儲條件?20°C外觀powder體外研究Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) areadded to the medium, it inhibits osteoblast proliferation in adose-dependent manner. In another group, bPTH are added to theculture medium from day 1 to day 10, but not from days 11 to 20, arebound of proliferation is observed in the PTH Day 1–10 groupafter bPTH withdrawal.Parathyroid Hormone (1-34), bovine (0.1-100ng/mL; 2-20 days) induces diverse effects on the calcium andphosphorus content of culture medium. The calcium and phosphoruscontent of culture medium in the PTH-C 100 ng/mL group are higherthan in teh control group. Cell Proliferation Assay Cell Line:MC3T3-E1 cells Concentration: 0.1-100 ng/mL Incubation Time: 2-20days Result: Resulted a decrease of osteoblast proliferationinconcentration-dependent manner. Resulted in a rebound ofproliferation when PTH withdrawal.體內(nèi)研究Parathyroid Hormone (1-34)(subcutaneousinjection; 80 μg/kg; 5 days)increases serum osteocalcin concentrations without changing seruminorganic phosphate or calcium concentrations in either group ofold animals.Serum 1,25-dihydroxyvitamin D concentrations aresignificantly higher in the PTH-treated senile female rats than thesex-matchedvehicle-treated controls.