中文名雷貝拉唑鈉
英文名Rebeprazolesodium
別名雷貝拉唑鈉
雷貝拉唑鈉鹽
雷貝拉唑鈉對(duì)照品
注射用雷貝拉唑鈉
雷貝拉唑-D4鈉鹽
雷貝拉唑鈉及中間體
2-{[4-(3-甲氧基丙氧基)-3-甲基吡啶-2-基]甲亞磺酰基}-1H-苯并咪唑鈉
英文別名PARIET
RABEPRAZOLSODIUM
SODIUMRABEPRAZOLE
RABEPRAZOLESODIUM
Rebeprazolesodium
rebeprazolesodium
RABEPRAZOLE,SODIUM SALT
(3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone
sodium2-[[4-(3-methoxypropoxy)-3-methyl-pyridin-2-yl]methylsulfinyl]benzoimidazole
[2-[[4-(3-methoxypropoxy)-3-methyl-2-pyridyl]methylsulfinyl]benzimidazol-1-yl]sodium
sodium2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)benzimidazol-1-ide
2-[[[4-(3-METHOXYPROPOXY)-3-METHYLPYRIDIN-2-YL]METHYL]SULFINY]-1H-BENZIMIDAZOLESODIUM SALT
2-[[[4-(3-METHOXYPROPOXY)-3-METHYL-2-PYRIDINYL]METHYL]SULFINYL]-1H-BENZIMIDAZOLE,SODIUM SALT
CAS117976-90-6
EINECS629-730-3化學(xué)式C18H20N3NaO3S
分子量381.42InChIInChI=1/C18H20N3O3S.Na/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18;/h3-4,6-9H,5,10-12H2,1-2H3;/q-1;+1/rC18H20N3NaO3S/c1-13-15(19-9-8-17(13)25-11-5-10-24-2)12-26(23)18-20-14-6-3-4-7-16(14)21(18)22/h3-4,6-9H,5,10-12H2,1-2H3InChIKeyKRCAOYSA-N熔點(diǎn)140-141°C dec.沸點(diǎn)603.9°C at 760 mmHg溶解度H2O: soluble10mg/mL (clear solution)存儲(chǔ)條件-20°C穩(wěn)定性Hygroscopic外觀powder顏色white to beigeMerck14,8089MDL號(hào)MFCD02092688體外研究對(duì)MKN-28細(xì)胞處理以rabeprazole將顯著降低其生存能力。Rabeprazole誘導(dǎo)AGS細(xì)胞大量凋亡，在MKN-28細(xì)胞中競(jìng)爭(zhēng)性抑制ERK1/2的磷酸化，而在KATOIII或MKN-45細(xì)胞沒(méi)有此效應(yīng)。Rabeprazole能有效地抑制胃癌細(xì)胞中ERK1/2的磷酸化，通過(guò)抑制ERK1/2信號(hào)通路，減弱人胃癌細(xì)胞的生存能力。體內(nèi)研究在胃大部切除術(shù)后大鼠中，Rabeprazole并不會(huì)惡化骨代謝紊亂，而是改善TG誘導(dǎo)的骨密度降低。