THPTA(tris-hydroxypropyltriazolylmethylamine) is a water-soluble, veryeffective accelerating ligand for copper-catalyzed Alkyne-Azideclick chemistry reactions (CuAAC). In addition to greatly enhancingthe rate of CuAAC, THPTA minimizes perturbations to thephysiological state of the cells or organisms probed and allows forthe effective bioconjugation with suppressed cell cytotoxicity byfurther lowering Cu loading in the catalyst formulation. Thewater-soluble THPTA ligand further simplifies click chemistry byallowing the entire reaction to be run in water.

THPTA（三羥丙基三唑基甲胺）是一種水溶性、非常有效的加速配體，用于銅催化的炔-疊氮點(diǎn)擊化學(xué)反應(yīng)(CuAAC)。 除了大大提高 CuAAC 的速率外，THPTA 還可以大限度地減少了對(duì)所探測(cè)細(xì)胞或生物體生理狀態(tài)的干擾，并通過(guò)進(jìn)一步降低催化劑配方中的Cu 負(fù)載量來(lái)實(shí)現(xiàn)有效的生物偶聯(lián)，同時(shí)抑制細(xì)胞的細(xì)胞毒性。 水溶性 THPTA配體通過(guò)允許整個(gè)反應(yīng)在水中進(jìn)行，進(jìn)一步簡(jiǎn)化了點(diǎn)擊化學(xué)。

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